A study by Yang et al, published in Environmental Health Perspectives, found that most plastic products release estrogenic substances.  Almost all commercially available plastic products we sampled—independent of the type of resin, product, or retail source—leached chemicals having reliably detectable estrogenic activity, including those advertised as BPA-free. In some cases, BPA-free products released chemicals having more estrogenic activity than did BPA-containing products.

in vitro data overwhelmingly show that exposures to chemicals having estrogenic activity (often in very low doses) change the structure and function of many human cell types (Gray 2008).  In addition, many in vitro and in vivo studies document in detail cellular/molecular/systemic mechanisms by which chemicals having estrogenic activity produce changes in various cells, organs, and behaviors (Gray 2008).

Several epidemiological studies (Gray 2008; Koch and Calafat 2009; Meeker et al. 2009; Swan et al. 2005; Talsness et al. 2009; Thompson et al. 2009) strongly suggest that chemicals having estrogenic activity produce measurable changes in the health of various human populations (e.g., on the offspring of mothers given diethylstilbestrol, or sperm counts in Danish males and other groups correlated with BPA levels in body tissues).