This meta-analysis by Rochester and Bolden, published in Environmental Health Perspectives, concludes that based on the current literature, the BPA substitutes BPS and BPF, are as hormonally active as BPA, and they have endocrine-disrupting effects.

Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled “BPA-free.” Some of the chemical replacements, however, are also bisphenols and may have similar physiological effects in organisms. Bisphenol S (BPS) and bisphenol F (BPF) are two such BPA substitutes.