Insufficient sleep affects circadian rhythm, gene expression, and immune response

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Insufficient sleep affects circadian rhythm, gene expression, and immune response

Fitness

Articles & Research

In a study published in PNAS, insufficient sleep was associated with negative health outcomes.

“We show that one wk of insufficient sleep alters gene expression in human blood cells, reduces the amplitude of circadian rhythms in gene expression, and intensifies the effects of subsequent acute total sleep loss on gene expression. The affected genes are involved in chromatin remodeling, regulation of gene expression, and immune and stress responses.”