In a study published in the Journal of Clinical Endocrinology & Metabolism, Major et al found that higher blood levels of IGF-I (Insulin-like Growth Factor, in older men was associated with increased risk of cancer death. Refined carbohydrates, like white flour, white rice, and sugars can raise IGF-1 levels, because they cause rapid increases in insulin levels, leading to increases in IGF-1 signaling. Read the study here.